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Soy Isoflavones
Westerners have been
slow to put tempeh, soy milk, tofu,
and other soybean products on the
table. But as evidence mounts that
compounds in soy--isoflavones--have
impressive health benefits, so too
does consumption of this Asian
dietary staple.
Soy isoflavones
are powerful plant substances
chemically similar to the female
hormone estrogen. Their presence in
soy foods may help to explain why
people in countries where soy is a
big part of the diet suffer from
relatively few menopausal symptoms
such as hot flashes. It may also
explain why rates of certain
hormone-related cancers are much
lower in Asia than they are in many
parts of the West, including the
United States.
While soy
isoflavones are now available in
supplement form, it remains to be
determined whether these pills can
provide the same health benefits as
soy isoflavones consumed as part of
the diet. In fact, most research has
been done on people who eat soy
products rather than take soy
supplements. It's possible that
isoflavones are just one of several
therapeutic compounds in soy. Still,
while it's ideal to get soy
isoflavones from one or two daily
servings of soy foods, supplements
are now an option for soy-leery
eaters.
Two particularly
important isoflavones in
soy--genistein and daidzein--appear
to protect against hormone-related
disorders such as breast cancer and
endometriosis. They do this by
competing for the same place on
cells (receptor sites) that the
body's own estrogen does. Some of
the risks of excess estrogen,
including breast and uterine cancer,
can apparently be lowered in this
way.
Similarly, when
the body's natural levels of
estrogen drop, as they do with
menopause, soy isoflavones can
compensate by binding to some of the
cell receptor sites that estrogen
once did. Menopausal symptoms may
improve as a result.
Research findings
suggest that soy isoflavones may
also inhibit cancer-causing enzymes,
provide antioxidant protection, and
enhance the immune system.
Specifically, soy
isoflavones may help to:
Control
symptoms of menopause and
perimenopause.
When regularly ingested, soy may
reduce the frequency and severity of
hot flashes and other menopausal
difficulties. In one study, women
who added 45 grams of soy flour to
their daily diet experienced a 40%
reduction in hot flashes. The
isoflavones in soy are believed to
be responsible for these effects.
Guard against
osteoporosis.
Soy isoflavones may aid women (and
men) in maintaining bone mineral
density. One study of postmenopausal
women found that consuming 40 grams
of soy protein a day resulted in a
significant increase in bone mineral
density in the spine, an area often
weakened by osteoporosis. If the
spine is weak, stooped posture and
myriad complications may develop.
Counteract the
effects of endometriosis.
The phytoestrogens in soy products
may help to offset the action of the
body's natural estrogen, which is
often responsible for instigating
the monthly pain, heavy bleeding,
and other symptoms of endometriosis.
Protect
against prostate problems.
Eating soy products may protect
against enlargement of the male
prostate gland. The size of the
prostate gland tends to increase
with age, causing various types of
urinary difficulties, including
frequent nighttime awakenings.
Prevent
various cancers.
Preliminary studies show that
regular consumption of soy foods or
supplements may protect against
hormone-related cancers of the
breast, prostate, and endometrium.
According to one study, women who
ate the most soy products and other
foods rich in phytoestrogens reduced
their risk of endometrial cancer by
54%.
Integrating soy
products may be especially important
for women who have never been
pregnant. One analysis found that
women in this category who consumed
little, if any, soy--less than a
quarter ounce in a given day, on
average--were at four times the risk
for developing endometrial cancer.
In animal studies, adding soy
protein to the diet significantly
reduced tumor formation and the
likelihood that cancer, once
developed, would spread. So even
though more research is needed on
soy's cancer-fighting properties,
researchers are hopeful. They
speculate that the isoflavone
genistein may block a protein called
tyrosine kinase, which promotes the
growth and proliferation of tumor
cells.
Reduce heart
disease risk.
Heart-healthy actions have been
attributed to isoflavone-rich soy.
In 1999 the Food and Drug
Administration declared that soy
foods can be billed as products that
reduce the risk of heart disease by
lowering harmful cholesterol.
Specifically, soy products have been
shown to lower LDL ("bad")
cholesterol and significantly
increase HDL ("good") cholesterol.
In one study,
people who drank a "milk shake"
containing 25 g of soy protein for
nine weeks experienced, on average,
a 5% reduction in LDL cholesterol.
And people with the highest LDL
levels experienced an 11% drop. (For
each 10% to 15% drop in the LDL
level, the risk of a heart attack
decreases 20% to 25%.) Because soy's
effects are less marked in people
with near-normal cholesterol levels,
individuals in this category will
need to take larger amounts of soy
to produce the same reductions. In
addition, soy products appear to
inhibit the oxidation of LDL
cholesterol that can eventually clog
arteries.
- tablet
- powder
- liquid
- capsule
Special tips:
The best way to
get soy isoflavones is through soy
foods. Such foods provide abundant
protein without the saturated fat
found in many other protein-rich
sources, such as red meat.
Experts have yet
to pinpoint the amount of soy
isoflavones needed to produce health
benefits. In Asian countries, where
the prevalence of disorders such as
breast cancer and invasive prostate
cancer is relatively low, people
consume soy foods in amounts that
provide an estimated 20 to 200 mg of
soy isoflavones a day.
If you decide to
take supplements, choose products
that supply a mixture of isoflavones
including genistein and daidzein.
High-quality
soy-based protein powders are widely
available and easy to use; simply
add the recommended number of scoops
to a cold or hot drink or a food
such as oatmeal or soup.
For the majority
of conditions mentioned: Try to
ingest a total of 100 mg twice a day
from supplements, foods, or a
combination of the two.
Take a pill
containing soy isoflavones with a
large glass of warm water before
eating breakfast and dinner.
A high-fiber diet
may interfere with the absorption of
soy isoflavones. Therefore, if your
diet is high in fiber, boost your
soy consumption.
There are no known
drug or nutrient interactions
associated with soy isoflavones.
Even large amounts of soy isoflavones obtained through
foods pose no apparent health risks.
However, much less is known about
the potential side effects of taking
soy isoflavones in concentrated
capsule form, and research into the
increased risk for breast cancer and
other reactions is ongoing.
A woman with a
strong family history of breast
cancer in particular should be aware
that in laboratory studies, soy
stimulates the growth of breast
cells. Whether this directly
translates into an increased risk
for breast cancer in humans is
poorly understood, however. Consult
your doctor for guidance.
A woman's decision to take soy isoflavone supplements
for any condition must be an
individualized one made in
consultation with a doctor familiar
with her medical background. This is
certainly the wisest approach until
research can reveal more details
about how soy isoflavones affect the
body--in both positive and negative
ways.
Because of their
estrogenlike effects, pregnant or
nursing women should not take soy
isoflavone supplements. (Soy-rich
foods pose no such problems,
however.)
Avoid all soy
supplements and soy-based foods if
you have an allergy to soybeans.
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Ailments
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Dosage
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Alcoholism |
1-2
scoops twice a day mixed
with juice
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Cancer |
Follow
package instructions
(usually 2 scoops twice
a day, mixed with
juice).
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Menopause |
50-100 mg
once or twice a day
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Perimenopause |
50-100 mg
once or twice a day
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Prostate
Problems |
2 500 mg
capsules (standardized
to contain 5% soy
isoflavones) each
morning
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